NDLI logo
  • Content
  • Similar Resources
  • Metadata
  • Cite This
  • Log-in
  • Fullscreen
Log-in
Do not have an account? Register Now
Forgot your password? Account recovery
  1. Medical and Biological Engineering and Computing
  2. Medical and Biological Engineering and Computing : Volume 45
  3. Medical and Biological Engineering and Computing : Volume 45, Issue 2, February 2007
  4. Propagation of pacemaker activity
Loading...

Please wait, while we are loading the content...

Medical and Biological Engineering and Computing : Volume 55
Medical and Biological Engineering and Computing : Volume 54
Medical and Biological Engineering and Computing : Volume 53
Medical and Biological Engineering and Computing : Volume 52
Medical and Biological Engineering and Computing : Volume 51
Medical and Biological Engineering and Computing : Volume 50
Medical and Biological Engineering and Computing : Volume 49
Medical and Biological Engineering and Computing : Volume 48
Medical and Biological Engineering and Computing : Volume 47
Medical and Biological Engineering and Computing : Volume 46
Medical and Biological Engineering and Computing : Volume 45
Medical and Biological Engineering and Computing : Volume 45, Issue 12, December 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 11, November 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 10, October 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 9, September 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 8, August 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 7, July 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 6, June 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 5, May 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 4, April 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 3, March 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 2, February 2007
Special issue on biopacemaking: clinically attractive, scientifically a challenge
Embryological development of pacemaker hierarchy and membrane currents related to the function of the adult sinus node: implications for autonomic modulation of biopacemakers
Creation of a biological pacemaker by gene- or cell-based approaches
Creating a cardiac pacemaker by gene therapy
Biological pacemakers based on I $_{f}$
Gene therapy to create biological pacemakers
Propagation of pacemaker activity
Computer modelling of the sinoatrial node ( Medical and Biological Engineering and Computing , Volume 45 , Issue 2 )
Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved
Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I $_{f}$-current density and connexin 40 mRNA levels in fetal cardiomyocytes
Medical and Biological Engineering and Computing : Volume 45, Issue 1, January 2007
Medical and Biological Engineering and Computing : Volume 44
Medical and Biological Engineering and Computing : Volume 43
Medical and Biological Engineering and Computing : Volume 42
Medical and Biological Engineering and Computing : Volume 41
Medical and Biological Engineering and Computing : Volume 40
Medical and Biological Engineering and Computing : Volume 39
Medical and Biological Engineering and Computing : Volume 38
Medical and Biological Engineering and Computing : Volume 37
Medical and Biological Engineering and Computing : Volume 36
Medical and Biological Engineering and Computing : Volume 35

Similar Documents

...
Computer modelling of the sinoatrial node ( Medical and Biological Engineering and Computing , Volume 45 , Issue 2 )

Article

...
Dual-chamber cardiac pacemaker tester

Article

...
Gene therapy to create biological pacemakers

Article

...
Creating a cardiac pacemaker by gene therapy

Article

...
Effect of heterogeneities in the cellular microstructure on propagation of the cardiac action potential

Article

...
Biological pacemakers based on I $_{f}$

Article

...
Computer modelling of the sinoatrial node ( Medical and Biological Engineering and Computing , Volume 45 , Issue 7 )

Article

...
Activities of the sinus node pacemaking during the simulated atrial reentry

Article

...
Computer simulation of wild-type and mutant human cardiac Na$^{+}$ current

Article

Propagation of pacemaker activity

Content Provider SpringerLink
Author Joyner, Ronald W. Wilders, Ronald Wagner, Mary B.
Copyright Year 2006
Abstract Spontaneous activity of specific regions (e.g., the Sinoatrial node, SAN) is essential for the normal activation sequence of the heart and also serve as a primary means of modulating cardiac rate by sympathetic tone and circulating catecholamines. The mechanisms of how a small SAN region can electrically drive a much larger atrium, or how a small ectopic focus can drive surrounding ventricular or atrial tissue are complex, and involve the membrane properties and electrical coupling within the SAN or focus region as well as the membrane properties, coupling conductance magnitudes and also regional distribution within the surrounding tissue. We review here studies over the past few decades in which mathematical models and experimental studies have been used to determine some of the design principles of successful propagation from a pacemaking focus. These principles can be briefly summarized as (1) central relative uncoupling to protect the spontaneously firing cells from too much electrotonic inhibition, (2) a transitional region in which the cell type and electrical coupling change from the central SAN region to the peripheral atrial region, and (3) a distributed anisotropy to facilitate focal activity.
Starting Page 177
Ending Page 187
Page Count 11
File Format PDF
ISSN 01400118
Journal Medical and Biological Engineering and Computing
Volume Number 45
Issue Number 2
e-ISSN 17410444
Language English
Publisher Springer-Verlag
Publisher Date 2006-09-02
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Sinoatrial node Electrical coupling Action potential propagation Cardiac rhythm Cardiac cell electrophysiology Numerical simulations Neurosciences Computer Applications Imaging Radiology Human Physiology Biomedical Engineering
Content Type Text
Resource Type Article
Subject Biomedical Engineering Computer Science Applications
  • About
  • Disclaimer
  • Feedback
  • Sponsor
  • Contact
  • Chat with Us
About National Digital Library of India (NDLI)
NDLI logo

National Digital Library of India (NDLI) is a virtual repository of learning resources which is not just a repository with search/browse facilities but provides a host of services for the learner community. It is sponsored and mentored by Ministry of Education, Government of India, through its National Mission on Education through Information and Communication Technology (NMEICT). Filtered and federated searching is employed to facilitate focused searching so that learners can find the right resource with least effort and in minimum time. NDLI provides user group-specific services such as Examination Preparatory for School and College students and job aspirants. Services for Researchers and general learners are also provided. NDLI is designed to hold content of any language and provides interface support for 10 most widely used Indian languages. It is built to provide support for all academic levels including researchers and life-long learners, all disciplines, all popular forms of access devices and differently-abled learners. It is designed to enable people to learn and prepare from best practices from all over the world and to facilitate researchers to perform inter-linked exploration from multiple sources. It is developed, operated and maintained from Indian Institute of Technology Kharagpur.

Learn more about this project from here.

Disclaimer

NDLI is a conglomeration of freely available or institutionally contributed or donated or publisher managed contents. Almost all these contents are hosted and accessed from respective sources. The responsibility for authenticity, relevance, completeness, accuracy, reliability and suitability of these contents rests with the respective organization and NDLI has no responsibility or liability for these. Every effort is made to keep the NDLI portal up and running smoothly unless there are some unavoidable technical issues.

Feedback

Sponsor

Ministry of Education, through its National Mission on Education through Information and Communication Technology (NMEICT), has sponsored and funded the National Digital Library of India (NDLI) project.

Contact National Digital Library of India
Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302
See location in the Map
03222 282435
Mail: support@ndl.gov.in
Sl. Authority Responsibilities Communication Details
1 Ministry of Education (GoI),
Department of Higher Education
Sanctioning Authority https://www.education.gov.in/ict-initiatives
2 Indian Institute of Technology Kharagpur Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project https://www.iitkgp.ac.in
3 National Digital Library of India Office, Indian Institute of Technology Kharagpur The administrative and infrastructural headquarters of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
4 Project PI / Joint PI Principal Investigator and Joint Principal Investigators of the project Dr. B. Sutradhar  bsutra@ndl.gov.in
Prof. Saswat Chakrabarti  will be added soon
5 Website/Portal (Helpdesk) Queries regarding NDLI and its services support@ndl.gov.in
6 Contents and Copyright Issues Queries related to content curation and copyright issues content@ndl.gov.in
7 National Digital Library of India Club (NDLI Club) Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach clubsupport@ndl.gov.in
8 Digital Preservation Centre (DPC) Assistance with digitizing and archiving copyright-free printed books dpc@ndl.gov.in
9 IDR Setup or Support Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops idr@ndl.gov.in
I will try my best to help you...
Cite this Content
Loading...