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  1. Medical and Biological Engineering and Computing
  2. Medical and Biological Engineering and Computing : Volume 45
  3. Medical and Biological Engineering and Computing : Volume 45, Issue 2, February 2007
  4. Biological pacemakers based on I $_{f}$
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Medical and Biological Engineering and Computing : Volume 55
Medical and Biological Engineering and Computing : Volume 54
Medical and Biological Engineering and Computing : Volume 53
Medical and Biological Engineering and Computing : Volume 52
Medical and Biological Engineering and Computing : Volume 51
Medical and Biological Engineering and Computing : Volume 50
Medical and Biological Engineering and Computing : Volume 49
Medical and Biological Engineering and Computing : Volume 48
Medical and Biological Engineering and Computing : Volume 47
Medical and Biological Engineering and Computing : Volume 46
Medical and Biological Engineering and Computing : Volume 45
Medical and Biological Engineering and Computing : Volume 45, Issue 12, December 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 11, November 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 10, October 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 9, September 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 8, August 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 7, July 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 6, June 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 5, May 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 4, April 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 3, March 2007
Medical and Biological Engineering and Computing : Volume 45, Issue 2, February 2007
Special issue on biopacemaking: clinically attractive, scientifically a challenge
Embryological development of pacemaker hierarchy and membrane currents related to the function of the adult sinus node: implications for autonomic modulation of biopacemakers
Creation of a biological pacemaker by gene- or cell-based approaches
Creating a cardiac pacemaker by gene therapy
Biological pacemakers based on I $_{f}$
Gene therapy to create biological pacemakers
Propagation of pacemaker activity
Computer modelling of the sinoatrial node ( Medical and Biological Engineering and Computing , Volume 45 , Issue 2 )
Application of mesenchymal stem cell-derived cardiomyocytes as bio-pacemakers: current status and problems to be solved
Enrichment of cardiac pacemaker-like cells: neuregulin-1 and cyclic AMP increase I $_{f}$-current density and connexin 40 mRNA levels in fetal cardiomyocytes
Medical and Biological Engineering and Computing : Volume 45, Issue 1, January 2007
Medical and Biological Engineering and Computing : Volume 44
Medical and Biological Engineering and Computing : Volume 43
Medical and Biological Engineering and Computing : Volume 42
Medical and Biological Engineering and Computing : Volume 41
Medical and Biological Engineering and Computing : Volume 40
Medical and Biological Engineering and Computing : Volume 39
Medical and Biological Engineering and Computing : Volume 38
Medical and Biological Engineering and Computing : Volume 37
Medical and Biological Engineering and Computing : Volume 36
Medical and Biological Engineering and Computing : Volume 35

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Biological pacemakers based on I $_{f}$

Content Provider SpringerLink
Author Rosen, Michael R. Brink, Peter R. Cohen, Ira S. Robinson, Richard B.
Copyright Year 2006
Abstract Biological pacemaking as a replacement for or adjunct to electronic pacemakers has been a subject of interest since the 1990s. In the following pages, we discuss the rational for and progress made using a hyperpolarization activated, cyclic nucleotide gated channel isoform to carry the I $_{f}$ pacemaker current in gene and cell therapy approaches. Both strategies have resulted in effective biological pacemaker function over a period of weeks in intact animals. Moreover, the use of adult human mesenchymal stem cells as a platform for carrying pacemaker genes has resulted in the formation of functional gap junctions with cardiac myocytes in situ leading to effective and persistent propagation of pacemaker current. The approaches described are encouraging, suggesting that biological pacemakers based on this strategy can be brought to clinical testing.
Starting Page 157
Ending Page 166
Page Count 10
File Format PDF
ISSN 01400118
Journal Medical and Biological Engineering and Computing
Volume Number 45
Issue Number 2
e-ISSN 17410444
Language English
Publisher Springer-Verlag
Publisher Date 2006-05-31
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword HCN isoforms Electronic pacemakers Sinoatrial node Atrioventricular block Gene therapy Cell therapy Neurosciences Computer Applications Imaging Radiology Human Physiology Biomedical Engineering
Content Type Text
Resource Type Article
Subject Biomedical Engineering Computer Science Applications
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