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  1. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
  2. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83
  3. Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83, Issue 2, June 2013
  4. Inhibition of In Vitro TNF-α Production by Anisomeles malabarica R.Br. Reinforces Its Anti-Rheumatic and Immunomodulatory Properties
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Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 87
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 86
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 85
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 84
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83, Issue 4, December 2013
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83, Issue 3, September 2013
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83, Issue 2, June 2013
RAPD Analysis to Study Metagenome Diversity in Soil Microbial Community of Arid Zone Plants
Role of Phytochemicals and Nucleic Acids in Solving Taxonomic Problems
Effect of Mycorrhizal Infection on Phosphorus Efficiency of Maize (Zea mays L.) Cultivars
Impact of Rainfall Pattern on Native Arbuscular-Mycorrhizal Activity Influencing Phosphorus Utilization by Direct Seeded Rainfed Upland Rice (Oryza sativa L.)
Molecular and Immunological Characterization of Heat Shock Protein 70 (HSP70) Gene from Buffalo
Bioactivity of Two Plant Derived Essential Oils Against the Rice Weevils Sitophilus oryzae (L.) (Coleoptera: Curculionidae)
Production of Enzymes and Culture Filtrates by Colletotrichum gloeosporioides Penz. Causing Banana Fruit Rot
Development of Recombinant Matrix Metalloproteinase-11 Based Sandwich ELISA for the Diagnosis of Canine Mammary Tumor
Inhibition of In Vitro TNF-α Production by Anisomeles malabarica R.Br. Reinforces Its Anti-Rheumatic and Immunomodulatory Properties
Parasitic Castration in Freshwater Snail Melanoides tuberculatus (Mollusca: Gastropoda)
Isolation, Purification and Partial Characterization of an Antibacterial Agent Produced by Halotolerant Alkaliphilic Streptomyces sp. EWC 7(2)
Alcohol-Mediated Horizontal Spread of Bacillus Spores and Assessing the Recurrent Sterilization Needs of Culture-Handling Tools Contaminated with Hardy Spores
Production of Alkalophilic Xylanases by Paenibacillus polymyxa CKWX1 Isolated from Decomposing Wood
Diversity of Halophilic Archaea at Salt Pans Around Bhavnagar Coast, Gujarat
Impact of Natural Fermentation on Physicochemical, Microbiological and Cup Quality Characteristics of Arabica and Robusta Coffee
Abnormal Leaf Morphologies Associated with Primary and Secondary Vein Patterning Defects in Catharanthus roseus: Mid-vein Defect Converts Simple Leaf into Binate Compound Leaf
Optimization of Agrobacterium-Mediated Genetic Transformation and Regeneration of Transgenic Plants in Indian Cultivar of Barley (Hordeum vulgare L. cv. BL 2)
Diversity of Arbuscular Mycorrhizal Fungal Spores Present in the Rhizospheric Soil of Four Different Grasses in Gujarat, India
Phytochemical Composition and Antioxidant Activity of Some Scorzonera Species
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 83, Issue 1, March 2013
Proceedings of the National Academy of Sciences, India Section B: Biological Sciences : Volume 82

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Inhibition of In Vitro TNF-α Production by Anisomeles malabarica R.Br. Reinforces Its Anti-Rheumatic and Immunomodulatory Properties

Content Provider SpringerLink
Author Shareef, M. Ismail Shariff, Anis Ahmed Leelavathi, S.
Copyright Year 2012
Abstract In-vivo studies have suggested the anti-rheumatic and immunomodulatory properties of the methanolic extract of the plant Anisomeles malabarica R.Br. However, the mechanism of action of this plant in the modulation of inflammation using the various in vitro models has not been explored earlier. Hence, the current investigation was undertaken to study the anti-rheumatic and immunomodulatory role of aerial parts, leaves and roots in lipopolysaccharide (LPS) mediated signaling in macrophage and mouse connective tissue cell cultures. It was observed from the present study that by employing tumor necrosis factor-α (TNF-α) bioassay, all the three extracts viz., aerial parts, leaves and roots inhibited TNF-α production in LPS (1 μg/mL) stimulated RAW-32 cells. 38.75 % inhibition of TNF-α was observed at 200 μg extracts of the aerial parts of the plant followed by 17.64 and 14.94 % by the roots and leaves respectively. Taken together, these findings from the present in vitro studies suggest the anti-rheumatic and immunomodulatory properties of the methanolic extracts of A. malabarica.
Starting Page 187
Ending Page 191
Page Count 5
File Format PDF
ISSN 03698211
Journal Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
Volume Number 83
Issue Number 2
e-ISSN 22501746
Language English
Publisher Springer-Verlag
Publisher Date 2012-12-05
Publisher Place India
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Life Sciences Plant Biochemistry Nucleic Acid Chemistry Anisomeles malabarica R.Br. Behavioural Sciences Lipopolysaccharide Anti-rheumatic Immunomodulatory Tumor necrosis factor-α Raw-32 cell lines
Content Type Text
Resource Type Article
Subject Environmental Science Agricultural and Biological Sciences
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