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  1. Medical and Biological Engineering and Computing
  2. Medical and Biological Engineering and Computing : Volume 38
  3. Medical and Biological Engineering and Computing : Volume 38, Issue 3, May 2000
  4. Validation of real-time continuous perfusion measurement
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Medical and Biological Engineering and Computing : Volume 55
Medical and Biological Engineering and Computing : Volume 54
Medical and Biological Engineering and Computing : Volume 53
Medical and Biological Engineering and Computing : Volume 52
Medical and Biological Engineering and Computing : Volume 51
Medical and Biological Engineering and Computing : Volume 50
Medical and Biological Engineering and Computing : Volume 49
Medical and Biological Engineering and Computing : Volume 48
Medical and Biological Engineering and Computing : Volume 47
Medical and Biological Engineering and Computing : Volume 46
Medical and Biological Engineering and Computing : Volume 45
Medical and Biological Engineering and Computing : Volume 44
Medical and Biological Engineering and Computing : Volume 43
Medical and Biological Engineering and Computing : Volume 42
Medical and Biological Engineering and Computing : Volume 41
Medical and Biological Engineering and Computing : Volume 40
Medical and Biological Engineering and Computing : Volume 39
Medical and Biological Engineering and Computing : Volume 38
Medical and Biological Engineering and Computing : Volume 38, Issue 6, November 2000
Medical and Biological Engineering and Computing : Volume 38, Issue 5, September 2000
Medical and Biological Engineering and Computing : Volume 38, Issue 4, July 2000
Medical and Biological Engineering and Computing : Volume 38, Issue 3, May 2000
Finite element analysis of brain contusion: An indirect impact study
A spot check for estimating stereophotogrammetric errors
Effectiveness of supplemental grasp-force feedback in the presence of vision
An artificial grasping evaluation system for the paralysed hand
New prototype NIRS to investigate multi-regional cerebral blood and tissue oxygenation and haemodynamics
Influence of measurement noise and electrode mislocalisation on EEG dipole-source localisation
Detection and multichannel SVD-based filtering of trigeminal somatosensory evoked potentials
An alpha modulation index for electroencephalographic studies using complex demodulation
Two-dimensional Chebyshev pseudospectral modelling of cardiac propagation
Validation of real-time continuous perfusion measurement
3D micro-computed tomography of trabecular and cortical bone architecture with application to a rat model of immobilisation osteoporosis
Anisotropy of Young's modulus of human tibial cortical bone
Modelling of chronic wound healing dynamics
Numerical model of deep venous thrombosis detection using venous occlusion strain gauge plethysmography
Influence of the size of syncytial units on synaptic potentials in smooth muscle
Spreading and motility of human glioblastoma cells on sheets of silicone rubber depend on substratum compliance
Medical and Biological Engineering and Computing : Volume 38, Issue 2, March 2000
Medical and Biological Engineering and Computing : Volume 38, Issue 1, January 2000
Medical and Biological Engineering and Computing : Volume 37
Medical and Biological Engineering and Computing : Volume 36
Medical and Biological Engineering and Computing : Volume 35

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Validation of real-time continuous perfusion measurement

Content Provider SpringerLink
Author Martin, G. T. Bowman, H. F.
Copyright Year 2000
Abstract Perfusion, the rate at which blood in tissue is replenished at the capillary level, is a primary factor in the transport of heat, drugs, oxygen and nutrients. While there have been many measurement techniques proposed, most do not lend themselves to routine, continuous and real-time use. A minimally invasive probe, called the thermal diffusion probe (TDP), which uses a self-heated thermistor to measure absolute perfusion continuously and in real time, was validated at low flows with the microsphere technique. In 27 rabbits, simultaneous TDP measurements were made in liver from 0 to 60 ml min$^{−1}$ 100 g$^{−1}$. The TDP perfusion correlated well with the microspheres (R$^{2}$=0.898) and the agreement between techniques is very good with a slope close to unity (0.921) and an intercept close to zero (0.566 ml min$^{−1}$ 100 g$^{−1}$). Variability between the two techniques was primarily due to the sampling error from the microsphere ‘snap shot’ of periodic blood flow when compared with the continuous TDP perfusion measurement. The ability to quantify local perfusion continuously and in real time may have a profound impact on patient management in a number of clinical areas such as organ transplantation, neurosurgery, oncology and others, in which quantitative knowledge of perfusion is of value.
Starting Page 319
Ending Page 325
Page Count 7
File Format PDF
ISSN 01400118
Journal Medical and Biological Engineering and Computing
Volume Number 38
Issue Number 3
e-ISSN 17410444
Language English
Publisher Springer-Verlag
Publisher Date 2000-01-01
Publisher Place Berlin, Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Blood flow Perfusion Thermal diffusion probe Microspheres Rabbits Human Physiology Computer Applications Neurosciences Imaging Radiology Biomedical Engineering
Content Type Text
Resource Type Article
Subject Biomedical Engineering Computer Science Applications
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