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  1. Molecular and General Genetics MGG
  2. Molecular and General Genetics MGG : Volume 287
  3. Molecular and General Genetics MGG : Volume 287, Issue 2, February 2012
  4. The optogenetic (r)evolution
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Molecular and General Genetics MGG : Volume 291
Molecular and General Genetics MGG : Volume 290
Molecular and General Genetics MGG : Volume 289
Molecular and General Genetics MGG : Volume 288
Molecular and General Genetics MGG : Volume 287
Molecular and General Genetics MGG : Volume 287, Issue 11-12, December 2012
Molecular and General Genetics MGG : Volume 287, Issue 10, October 2012
Molecular and General Genetics MGG : Volume 287, Issue 9, September 2012
Molecular and General Genetics MGG : Volume 287, Issue 8, August 2012
Molecular and General Genetics MGG : Volume 287, Issue 7, July 2012
Molecular and General Genetics MGG : Volume 287, Issue 6, June 2012
Molecular and General Genetics MGG : Volume 287, Issue 5, May 2012
Molecular and General Genetics MGG : Volume 287, Issue 4, April 2012
Molecular and General Genetics MGG : Volume 287, Issue 3, March 2012
Molecular and General Genetics MGG : Volume 287, Issue 2, February 2012
The optogenetic (r)evolution
Thermodynamic and molecular analysis of the AbrB-binding sites within the phyC-region of Bacillus amyloliquefaciens FZB45
The Y-segment of novel cold dehydrin genes is conserved and codons in the PR-10 genes are under positive selection in Oxytropis (Fabaceae) from contrasting climates
Modulation of AUXIN-BINDING PROTEIN 1 gene expression in maize and the teosintes by transposon insertions in its promoter
A crossover hotspot near his-3 in Neurospora crassa is a preferential recombination termination site
Validation of reference genes for gene expression studies in peanut by quantitative real-time RT-PCR
A further study on chromosome minimization by protoplast fusion in Aspergillus oryzae
Molecular and General Genetics MGG : Volume 287, Issue 1, January 2012
Molecular and General Genetics MGG : Volume 286
Molecular and General Genetics MGG : Volume 285
Molecular and General Genetics MGG : Volume 284
Molecular and General Genetics MGG : Volume 283
Molecular and General Genetics MGG : Volume 282
Molecular and General Genetics MGG : Volume 281
Molecular and General Genetics MGG : Volume 280
Molecular and General Genetics MGG : Volume 279
Molecular and General Genetics MGG : Volume 278
Molecular and General Genetics MGG : Volume 277
Molecular and General Genetics MGG : Volume 276
Molecular and General Genetics MGG : Volume 275
Molecular and General Genetics MGG : Volume 274
Molecular and General Genetics MGG : Volume 273
Molecular and General Genetics MGG : Volume 272
Molecular and General Genetics MGG : Volume 271
Molecular and General Genetics MGG : Volume 270
Molecular and General Genetics MGG : Volume 269
Molecular and General Genetics MGG : Volume 268
Molecular and General Genetics MGG : Volume 267
Molecular and General Genetics MGG : Volume 266
Molecular and General Genetics MGG : Volume 265
Molecular and General Genetics MGG : Volume 264
Molecular and General Genetics MGG : Volume 263
Molecular and General Genetics MGG : Volume 262
Molecular and General Genetics MGG : Volume 261
Molecular and General Genetics MGG : Volume 260
Molecular and General Genetics MGG : Volume 259
Molecular and General Genetics MGG : Volume 258
Molecular and General Genetics MGG : Volume 257
Molecular and General Genetics MGG : Volume 256
Molecular and General Genetics MGG : Volume 255
Molecular and General Genetics MGG : Volume 254
Molecular and General Genetics MGG : Volume 253

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The optogenetic (r)evolution

Content Provider SpringerLink
Author Rein, Martin L. Deussing, Jan M.
Copyright Year 2011
Abstract Optogenetics is a rapidly evolving field of technology that allows optical control of genetically targeted biological systems at high temporal and spatial resolution. By heterologous expression of light-sensitive microbial membrane proteins, opsins, cell type-specific depolarization or silencing can be optically induced on a millisecond time scale. What started in a petri dish is applicable today to more complex systems, ranging from the dissection of brain circuitries in vitro to behavioral analyses in freely moving animals. Persistent technical improvement has focused on the identification of new opsins, suitable for optogenetic purposes and genetic engineering of existing ones. Optical stimulation can be combined with various readouts defined by the desired resolution of the experimental setup. Although recent developments in optogenetics have largely focused on neuroscience it has lately been extended to other targets, including stem cell research and regenerative medicine. Further development of optogenetic approaches will not only highly increase our insight into health and disease states but might also pave the way for a future use in therapeutic applications.
Starting Page 95
Ending Page 109
Page Count 15
File Format PDF
ISSN 16174615
Journal Molecular and General Genetics MGG
Volume Number 287
Issue Number 2
e-ISSN 16174623
Language English
Publisher Springer-Verlag
Publisher Date 2011-12-20
Publisher Place Berlin/Heidelberg
Access Restriction One Nation One Subscription (ONOS)
Subject Keyword Optogenetics Rhodopsin Channelrhodopsin Halorhodopsin Optical tools Arch ChR2 NpHR Microbial Genetics and Genomics Animal Genetics and Genomics Biochemistry Cell Biology Plant Genetics & Genomics
Content Type Text
Resource Type Article
Subject Genetics Medicine Molecular Biology
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